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Advanced Cardiovascular MRI


MRI is an indispensible tool to understand heart disease in our animal models.  Browse our collection of advanced MRI methods of heart disease!



Hemodynamics

 Left Ventricular Flow  Right Ventricular Flow
Fully oxygenated left atrial flow enters the left ventricle and forms complex subvalvular vortices. Vortex formation time and size appears to be related to ventricular geometry and valve function. During systole, flow exiting the ventricle enters the aortic root at high velocity towards the arch. Right ventricular hemodynamics visualized using 3D phase contrast magnetic resonance imaging ("4D Flow"). Venous return to the heart (red) enters the right atrium and descends through the tricuspid valve into the right ventricle. Right ventricular flow (yellow) leaves the right heart through the pulmonary valve to enter the pulmonary artery. Main pulmonary arterial flow (green) enters the pulmonary braches (blue).





Structural Heart Imaging 



Short Axis Cine Magnetic Resonance Imaging 3D Strain Imaging

 
 


 Scar and Borderzone Biochemical & Molecular Imaging


T1rho Magnetic Resonance Imaging
T1R and LGE
 T1R LGE copy



Imaging Methods: A Summary


Table 1: MRI imaging capabilities and new developments in the Gorman Cardiovascular Research Group

Biomarker Standard Methods  New Developments   References
systolic function
  • cine-bSSFP
  • SPAMM
  • 4D SPAMM 
  • Real-Time CMR

Xu, et al. J Cardiovasc Magn Reson (2010)

Blom, et al. Ann Thorac Surg (2007)

diastolic relaxation
  •  cine-bSSFP

infarct characterization

  • infarct mass
  • wall thickness
  • fibrosis
  • edema
  • late gadolinium enhanced MRI (LGE-MRI)
  • T2 and T1-weighted imaging
  •  T1R relaxation time mapping

New! Witschey, et al. JCMR (2012)

Witschey, et al. Magn Reson Med (2011)

hemodynamics
  •  Phase contrast MRI
  •  4D Flow
perfusion
  •  first pass, contrast enhanced MRI

 
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